Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease
Identifieur interne : 000C65 ( Main/Exploration ); précédent : 000C64; suivant : 000C66Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease
Auteurs : Irena Rektorova [République tchèque] ; Hana Srovnalova [République tchèque] ; Radka Kubikova [République tchèque] ; Jiri Prasek [République tchèque]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-08-15.
English descriptors
Abstract
We studied whether the 123I‐FP‐CIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). Twenty patients with PD without major depression and/or dementia (mean age 61.7 ± 12.7 years) underwent the 123I‐FP‐CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and 123I‐FP‐CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with 123I‐FP‐CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22158
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease</title><author><name sortKey="Rektorova, Irena" sort="Rektorova, Irena" uniqKey="Rektorova I" first="Irena" last="Rektorova">Irena Rektorova</name></author><author><name sortKey="Srovnalova, Hana" sort="Srovnalova, Hana" uniqKey="Srovnalova H" first="Hana" last="Srovnalova">Hana Srovnalova</name></author><author><name sortKey="Kubikova, Radka" sort="Kubikova, Radka" uniqKey="Kubikova R" first="Radka" last="Kubikova">Radka Kubikova</name></author><author><name sortKey="Prasek, Jiri" sort="Prasek, Jiri" uniqKey="Prasek J" first="Jiri" last="Prasek">Jiri Prasek</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:03BB200A22E8AA8FD7F447A017A40A488B458E67</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.22158</idno><idno type="url">https://api.istex.fr/document/03BB200A22E8AA8FD7F447A017A40A488B458E67/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000F42</idno><idno type="wicri:Area/Main/Curation">000D65</idno><idno type="wicri:Area/Main/Exploration">000C65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease</title><author><name sortKey="Rektorova, Irena" sort="Rektorova, Irena" uniqKey="Rektorova I" first="Irena" last="Rektorova">Irena Rektorova</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Srovnalova, Hana" sort="Srovnalova, Hana" uniqKey="Srovnalova H" first="Hana" last="Srovnalova">Hana Srovnalova</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Kubikova, Radka" sort="Kubikova, Radka" uniqKey="Kubikova R" first="Radka" last="Kubikova">Radka Kubikova</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Prasek, Jiri" sort="Prasek, Jiri" uniqKey="Prasek J" first="Jiri" last="Prasek">Jiri Prasek</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Nuclear Medicine, Masaryk University, Teaching Hospital Bohunice, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-08-15">2008-08-15</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1580">1580</biblScope><biblScope unit="page" to="1587">1587</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">03BB200A22E8AA8FD7F447A017A40A488B458E67</idno><idno type="DOI">10.1002/mds.22158</idno><idno type="ArticleID">MDS22158</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DaT scan</term><term>Parkinson's disease</term><term>Tower of London task</term><term>cognitive</term><term>depressive</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied whether the 123I‐FP‐CIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). Twenty patients with PD without major depression and/or dementia (mean age 61.7 ± 12.7 years) underwent the 123I‐FP‐CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and 123I‐FP‐CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with 123I‐FP‐CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>République tchèque</li></country><region><li>Moravie</li></region><settlement><li>Brno</li></settlement></list><tree><country name="République tchèque"><region name="Moravie"><name sortKey="Rektorova, Irena" sort="Rektorova, Irena" uniqKey="Rektorova I" first="Irena" last="Rektorova">Irena Rektorova</name></region><name sortKey="Kubikova, Radka" sort="Kubikova, Radka" uniqKey="Kubikova R" first="Radka" last="Kubikova">Radka Kubikova</name><name sortKey="Prasek, Jiri" sort="Prasek, Jiri" uniqKey="Prasek J" first="Jiri" last="Prasek">Jiri Prasek</name><name sortKey="Srovnalova, Hana" sort="Srovnalova, Hana" uniqKey="Srovnalova H" first="Hana" last="Srovnalova">Hana Srovnalova</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C65 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C65 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:03BB200A22E8AA8FD7F447A017A40A488B458E67
|texte= Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |